Methods of regulating protein glycosylation

Details Methods of regulating protein glycosylation Methods of regulating protein glycosylation

C - Chemistry, Metallurgy

12

N

195/1.23, 195/1.

C12N 15/11 (2006.01) C12N 1/19 (2006.01) C12N 9/60 (2006.01) C12N 9/72 (2006.01) C12N 15/52 (2006.01) C12N 15/81 (2006.01) C12Q 1/02 (2006.01) C12Q 1/04 (2006.01)

Patent

CA 1325781

Abstract of the Disclosure Methods for producing a heterologous protein or polypeptide are disclosed. A preferred method utilizes a fungal cell carrying a defect in a gene whose product is required for the addition of outer chain oligosaccharide moieties to glycoproteins, the cell transformed with a first DNA construct comprising a regulated promoter followed downstream by a DNA sequence which complements the defect, and a second DNA construct comprising a second promoter followed downstream by a DNA sequence encoding a secretion signal and a DNA sequence encoding a heterologous protein or polypeptide. A yeast cell having a Mnn9- phenotype and copyboy of producing colonies of normal morphologies in the absence of osmotic stabilization is also disclosed.

581625

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