Methods of regulating renalase (monoamine oxidase c)

A - Human Necessities – 61 – K

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A61K 38/44 (2006.01) C07H 21/04 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2630085

The present invention provides methods of using Monoamine Oxidase C (MAO-C), also known as renalase, as a therapeutic protein in its active and inactive forms. Administering inactive renalase protein to individuals with lower renalase levels can be used to provide them with an adequate pool of the protein that can be activated by the body as needed. Active renalase protein can be administered to individuals needing an immediate reduction of catecholamine levels. An inhibitor of renalase may be used to enhance adrenergic action.

La présente invention concerne des procédés d'utilisation de la monoamine oxydase C (MAO-C), également connue sous le nom de rénalase, comme protéine thérapeutique à la fois dans sa forme active et dans sa forme inactive. On peut recourir à l'administration de la protéine rénalase inactive à des personnes qui présentent de bas niveaux de rénalase pour leur fournir une réserve adéquate de la protéine qui peut être activée par le corps en fonction de ses besoins. La protéine rénalase active peut être administrée à des personnes dont le niveau de catécholamine doit être réduit de manière immédiate. On peut utiliser un inhibiteur de la rénalase pour renforcer l'action adrénergique.

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