Methods of regulating the condition of mammalian keratinous...

A - Human Necessities – 61 – K

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A61K 31/7048 (2006.01) A61K 31/465 (2006.01) A61K 31/522 (2006.01) A61K 45/00 (2006.01) A61P 17/04 (2006.01) A61P 17/16 (2006.01)

Patent

CA 2373194

The present invention relates to various methods for regulating the condition of mammalian keratinous tissue wherein the methods comprise the step of topically applying to the keratinous tissue of a mammal in need of such treatment a safe and effective amount of a composition comprising: a) a safe and effective amount of a repair agent consisting essentially of a xanthine compound selected from the group consisting of theophylline, theobromine, and combinations thereof; and b) a dermatologically acceptable carrier for the repair agent. In particular embodiments, such compositions or modified versions thereof are suitable for regulating visible and/or tactile discontinuities in the texture of mammalian skin, preventing and/or retarding the appearance of spider vessels and/or red blotchiness on mammalian skin, preventing and/or retarding the appearance of dark circles under the eye of a mammal as well as their puffy eyes, desquamating mammalian skin, preventing and/or retarding sallowness of mammalian skin, preventing and/or retarding sagging of mammalian skin, softening and/or smoothing lips, hair and nails of a mammal, and preventing and/or relieving itch of mammalian skin.

L'invention concerne différents procédés permettant de normaliser l'état des tissus cornés chez le mammifère. Ces procédés comprennent une étape caractérisée par l'application topique sur le tissu corné d'un mammifère nécessitant un tel traitement d'une quantité sûre et efficace d'une composition contenant : a) une quantité sûre et efficace d'un agent réparateur comprenant principalement un composé de xanthine sélectionné dans le groupe comprenant la théophylline, la théobromine, et des combinaison de celles-ci ; et b) un excipient dermatologiquement acceptable pour cet agent réparateur. Dans des formes de réalisation particulières, ces compositions ou des versions modifiées de ces dernières permettent de régulariser chez le mammifère les discontinuités visibles et/ou tactiles de la texture de la peau, de prévenir et/ou de retarder l'apparition de couperose et/ou de rougeurs sur la peau, de prévenir et/ou de retarder la formation de cernes sous les yeux ainsi que le gonflement des tissus entourant les yeux, d'exfolier la peau, de prévenir et/ou de retarder l'altération du teint, de prévenir et/ou retarder le relâchement cutané, d'assouplir et/ou de lisser les lèvres, les cheveux et les ongles, et de prévenir et/ou de soulager les démangeaisons de la peau.

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