Methods of replicating virus in monocyte-derived macrophage...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/85 (2006.01) C12N 5/06 (2006.01) C12N 7/00 (2006.01)

Patent

CA 2305622

The present invention provides methods of latent virus reactivation in monocyte-drived macrophages through allogeneic stimulation of peripheral blood mononuclear cells ("PBMC"), methods of culturing virus, and cultures of virally permissive monocyte-derived macrophages.

La présente invention concerne des procédés de réactivation de virus latent dans des macrophages dérivés de monocytes par la stimulation allogénique des cellules mononucléaires du sang périphérique (PBMC), des méthodes de culture de virus et des cultures de macrophages dérivés de monocytes à permissivité virale.

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