C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 48/00 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) A61P 25/30 (2006.01) C07K 16/28 (2006.01) C12N 9/12 (2006.01) G01N 33/50 (2006.01) G01N 33/567 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2491286
The present invention relates to methods of treating disease by altering G protein coupled receptor kinase (GRK) 6. This may be done by altering the expression or activity of the protein, for example. The present invention may be used for disease diagnosis, by detecting the expression or activity of GRK6. The present invention relates to a GRK6 deficient mouse, GRK6 splice variants, and methods of use. The present invention also relates to methods of identifying compounds that alter GRK6 activity. The present invention relates to disease treatment by altering GRK6 expression or activity.
La présente invention concerne des procédés permettant de traiter une maladie en modifiant la protéine kinase GR 6 (GRK6). On a la possibilité, pour cela, de modifier l'expression ou l'activité de la protéine, par exemple. La présente invention peut être utilisée pour diagnostiquer une maladie, en détectant l'expression ou l'actvité de la GRK6. L'invention concerne également une souris déficiente en GRK6, des variantes de l'épissure de la GRK6, et des procédés d'utilisation. L'invention concerne aussi des procédés d'identification de composés modifiant l'activité de la GRK6. L'invention concerne enfin le traitement de maladies par modification de l'expression ou de l'actvité de la GRK6.
Caron Marc G.
Gainetdinov Raul R.
Lefkowitz Robert J.
Premont Richard T.
Duke University
Marks & Clerk
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