Methods of screening for antagonists of apm1/gzip

Details Methods of screening for antagonists of apm1/gzip Methods of screening for antagonists of apm1/gzip

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 3/04 (2006.01) C07K 14/47 (2006.01) A61K 9/00 (2006.01) A61K 9/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2461491

The present invention relates to the field of metabolic research. Metabolic disorders, such as besity, are a public health problem that is serious and widespread. GZIP polypeptides have been identified that are believed to be beneficial in the treatment of metabolic disorders. These compounds should be effective for reducing body mass and for treating metabolic-related diseases and disorders. These metabolic-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.

L'invention concerne le domaine de la recherche métabolique. Les troubles métaboliques, notamment l'obésité, constituent un problème de santé publique sérieux et répandu. Les polypeptides GZIP ont été identifiés et s'avèrent avoir un effet bénéfique dans le traitement des troubles métaboliques. Ces composés doivent être efficaces pour réduire la masse corporelle et pour traiter les maladies et les troubles associés au métabolisme. Ces maladies et ces troubles associés au métabolisme comprennent les hyperlipidémies, l'athérosclérose, les diabètes et l'hypertension.

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