Methods of screening for compounds that inhibit the...

C - Chemistry – Metallurgy – 12 – N

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C12N 15/54 (2006.01) C12N 9/10 (2006.01) C12N 15/00 (2006.01) C12N 15/30 (2006.01) C12Q 1/18 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2704070

The present inventors succeeded in isolating GWT1 (PfGWT1), which is one of the enzymes involved in GPI biosynthesis in the malaria parasite P. falciparum. In addition, the inventors revealed that degenerate mutant DNAs, with a lower AT content than the DNA encoding the PfGWT1 protein, can complement the phenotype of GWT1--deficient yeast. Based on the findings, the present invention provides the GWT1 protein of malaria parasites and the use of the protein in methods of screening for antimalarial drugs. The present invention also provides degenerate mutant DNAs encoding proteins involved in GPI biosynthesis, and which have a lower AT content than the original DNAs. The present invention also provides methods of screening for antimalarial drugs which use the degenerate mutant DNAs.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Methods of screening for compounds that inhibit the... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of screening for compounds that inhibit the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of screening for compounds that inhibit the... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1923507

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.