A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/472 (2006.01) A61K 31/44 (2006.01) A61P 33/06 (2006.01)
Patent
CA 2721200
The present inventors succeeded in isolating GWT1 (PfGWT1), which is one of the enzymes involved in GPI biosynthesis in the malaria parasite P. falciparum. In addition, the inventors revealed that degenerate mutant DNAs, with a lower AT content than the DNA encoding the PfGWT1 protein, can complement the phenotype of GWT1-deficient yeast. Based on the findings, the present invention provides the GWT1 protein of malaria parasites and the use of the protein in methods of screening for antimalarial drugs. The present invention also provides degenerate mutant DNAs encoding proteins involved in GPI biosynthesis, and which have a lower AT content than the original DNAs. The present invention also provides methods of screening for antimalarial drugs which use the degenerate mutant DNAs.
Hata Katsura
Horii Toshihiro
Nakamoto Kazutaka
Ogawa Kaoru
Sagane Koji
Eisai R&d Management Co. Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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