G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/566 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) G01N 33/539 (2006.01) G01N 33/74 (2006.01) G01N 33/78 (2006.01)
Patent
CA 2444669
The present invention provides methods for identifying an effective agent that modulates a biological activity of a nuclear hormone receptor. In a method of the invention, an isolated receptor-containing complex is assayed for an altered modification state as compared to a control modification state. The presence of an altered modification state serves to identify an effective agent that modulates a biological activity of the nuclear hormone receptor.
La présente invention concerne des procédés permettant d'identifier un agent efficace modulant l'activité biologique d'un récepteur nucléaire d'hormones. Selon un procédé de l'invention, on analyse un complexe contenant un récepteur isolé à la recherche d'un état de modification perturbé par comparaison avec un état de modification témoin. La présence d'un état de modification perturbé permet d'identifier un agent efficace modulant l'activité biologique du récepteur nucléaire d'hormones.
Chandraratna Roshantha A.
Kusari Jyotirmoy
Thacher Scott M.
Xiao Jia-Hao
Zhao Yi
Allergan Inc.
Gowling Lafleur Henderson Llp
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