Methods of screening for crohn's disease using tnf...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2190586

A novel association between certain tumor necrosis factor microsatellite alleles and Crohn's disease has been discovered. In accordance with the present invention, there is provided methods for screening for Crohn's disease comprising detecting the presence or absence of nucleic acid of a subject encoding TNF microsatellite alleles associated with Crohn's disease, wherein the presence of nucleic acid encoding three or more of the alleles is indicative of Crohn's disease. Kits useful for screening for Crohn's disease are also provided which comprise nucleic acid encoding TNF microsatellite alleles associated with Crohn's disease.

On a découvert une nouvelle association entre certains allèles microsatellites du facteur de nécrose tumorale et la maladie de Crohn. La présente invention décrit des procédés pour dépister la maladie de Crohn, consistant à détecter chez un sujet la présence ou l'absence d'acide nucléique codant pour des allèles microsatellites du facteur de nécrose tumorale associés à la maladie de Crohn, la présence d'acide nucléique codant pour au moins trois de ces allèles révélant la maladie de Crohn. Sont également décrites des trousses utiles pour détecter la maladie de Crohn, qui comportent de l'acide nucléique codant pour des allèles microsatellites du facteur de nécrose tumorale associés à la maladie de Crohn.

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