C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2428543
The present invention relates to the identification and isolation of a novel family of ADP ribose (ADPR) regulated calcium transmembrane channel polypeptides designated herein as "LTRPC2" (Long Transient Receptor Potential Channel). Channels comprising these polypeptides open in response to concentrations of cytoplasmic ADPR in the micromolar range, exhibit enhanced activity in the presence of high intracellular levels of calcium, and do not respond to depletion or reduction in intracellular calcium stores. The invention further relates to the methods of utilizing LTRPC2 for binding, and the methods for modulating LTRPC2 activity and for measuring LTRPC2 permeability. The invention further relates to the methods of modulating expression of LTRPC2.
La présente invention concerne l'identification et l'isolement d'une nouvelle famille de polypeptides du canal transmembrane du calcium régulés par les riboses ADP (ADPR) et ci-après désignés les "LTRPC2" (Long Transient Receptor Potential Channel). Les canaux contenant ces polypeptides s'ouvrent en réaction aux concentrations d'ADPR cytoplasmique au niveau de la micromole, font preuve d'une activité renforcée en présence de niveaux élevés de calcium intracellulaire, sans réagir à la déplétion ou la réduction affectant les stocks de calcium intracellulaire. L'invention concerne également des procédés d'utilisation des LTRPC2 pour la liaison et de procédés de modulation de l'activité des LTRPC2 et de mesure de la perméabilité aux LTRPC2. L'invention concerne enfin des procédés de modulation de l'expression des LTRPC2.
Fleig Andrea
Penner Reinhold
Smart & Biggar
The Queen's Medical Center
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