Methods of screening for nucleoside analogs that are...

Details Methods of screening for nucleoside analogs that are... Methods of screening for nucleoside analogs that are...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/70 (2006.01) A61K 31/7064 (2006.01) C07H 19/06 (2006.01) C07H 19/073 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2194153

Methods and compositions related to HIV are disclosed. Using the methods of the present invention, nucleoside analogs may be screened for the ability to be incorporated by reverse transcriptase of human immunodeficiency virus ("HIV RT") and cause incorrect base pairing. Progressive mutation of the virus by such nucleoside analogs renders it non-viable.

L'invention concerne des procédés et des compositions relatifs au VIH. Selon les procédés de l'invention, on peut cribler des analogues de nucléosides afin de déterminer leur capacité à être incorporés par la transcriptase inverse du virus d'immunodéficience humaine et provoquer un appariement incorrect entre bases. La mutation progressive du virus induite par de tels analogues de nucléosides permet de le rendre non viable.

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