Methods of screening for trpm5 modulators

Details Methods of screening for trpm5 modulators Methods of screening for trpm5 modulators

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/52 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2516651

The invention relates to methods useful in identifying molecules that bind TRPM5, which modulate TRPM5 ion channel activity, and/or which alter expression of TRPM5 within cells. The TRPM5 channels as described herein contain TRPM5 polypeptides, which are in turn encoded by TRPM5 nucleic acids. The ion channels described herein are preferably formed in HEK-293 cells from one or more novel TRPM5 polypeptides, which exhibit one or more of the unique TRPM5 properties described herein.

L'invention concerne des méthodes utiles pour identifier des molécules fixant TRPM5, lesquelles modulent l'activité de canaux ioniques des TRPM5, et/ou qui modifient l'expression de TRPM5 à l'intérieur des cellules. Les canaux à TRPM5 tels qu'ils sont ici décrits contiennent des polypeptides TRPM5 qui sont à leur tour codés par des acides nucléiques de TRPM5. Les canaux ioniques ici décrits sont de préférence formés dans des cellules HEK-293 pour un ou pour plusieurs nouveaux polypeptides TRPM5, lesquels présentent une ou plusieurs des propriétés uniques de TRPM5 ici décrites.

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