G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/92 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2459945
The invention relates to compositions and methods for the screening of molecules that are used to prevent or treat metabolic syndrome, cardiovascular diseases and/or atherosclerosis. In particular, the invention relates to methods and kits for screening compounds based on determining the effect of test compounds on the activity of a novel protein which is similar to apolipoprotein AIV. The invention also relates to compositions and methods for reducing the concentration of triglycerides and/or reducing the concentration or the expression of apolipoprotein CIII (apo CIII) and/or reducing the concentration of VLDL and/or increasing the activity of LpL and/or of HL and/or increasing reverse cholesterol transport.
La présente invention concerne des compositions et méthodes de criblage de molécules utiles pour la prévention ou le traitement du syndrome métabolique, des maladies cardiovasculaires et/ou de l'athérosclérose. L'invention concerne notamment des méthodes et des kits de criblage de composés basées sur la détermination de l'effet de composés tests sur l'activité d'une nouvelle protéine apparentée à l'apolipoprotéine AIV. L'invention concerne également des compositions et méthodes pour diminuer la concentration de triglycérides et/ou pour diminuer la concentration ou l'expression de l'apolipoprotéine CIII (apo CIII) et/ou pour diminuer la concentration de VLDL et/ou pour augmenter l'activité de la LpL et/ou de la HL et/ou pour augmenter le transport inverse du cholestérol.
Majd Zouher
Najib Jamila
Genfit
Robic
LandOfFree
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