C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) A01K 67/00 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01) G01N 33/00 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2359798
The present invention relates generally to the side effects caused by retroviral therapies, including protease inhibitors, nucleoside reverse transcriptase inhibitors, and non-nucleoside reverse transcriptase inhibitors. Specifically, the present invention provides methods of screening a protease inhibitor for its capacity to affect symptoms or clinical conditions associated with lipodystrophy or dyslipidemia and related metabolic disorders, such as metabolic syndrome X, obesity, cardiovascular disorders, and impaired glucose tolerance in diabetes, in a patient.
La présente invention concerne de manière générale les effets secondaires provoqués par les thérapies rétrovirales, notamment les inhibiteurs de protéase, les inhibiteurs nucléosidiques de transcriptase inverse, et les inhibiteurs non-nucléosidiques de transcriptase inverse. De manière plus spécifique, cette invention concerne des procédés de criblage d'inhibiteur de protéase pour sa capacité à affecter les symptômes ou les états cliniques associés à la lipodystrophie ou dyslipidémie et les troubles métaboliques connexes, comme par exemple le syndrome X métabolique, l'obésité, les troubles cardiovasculaires, et l'intolérance au glucose en cas de diabète, chez un patient.
Glaxo Group Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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