Methods of selectively treating diseases with specific...

A - Human Necessities – 61 – K

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A61K 31/728 (2006.01)

Patent

CA 2572154

The present invention demonstrates that defined, specific GAG molecules have discerned differential effects, and that different types of cancers are prevented from proliferating and/or killed by oligosaccharides of different sizes; one size sugar does not treat all cancers effectively. Likewise, certain size GAGs have more potent angiogenic properties; thus, mixtures of different sizes of GAG molecules are not optimal. Therefore, the present invention is directed to methods of "personalized medicine", in which customized defined, specific GAG molecules are administered to a patient, wherein the defined, specific GAG molecules are chosen based on the specific ailment from which the patient is suffering and/or the response of in vitro testing of the ability of the defined, specific GAG molecules to treat, inhibit and/or prevent the ailment in a sample from the patient.

La présente invention démontre que des molécules GAG spécifiques définies ont des effets différenciés et que la prolifération de differents types de cancers est inhibée et/ou qu'ils sont supprimés par des oligosaccharides de différentes tailles; une taille de glucide ne traite pas tous les cancers efficacement. En outre, des GAG d'une certaine taille ont plus de propriétés angiogéniques puissantes. Ainsi les mélanges de molécules GAG de différentes tailles ne sont pas optimum. La présente invention concerne donc des procédés de <= médecine personnalisée >= selon laquelle des molécules GAG spécifiques définies de manière adaptée sont administrées à un patient, les molécules GAG spécifiques définies étant choisies sur la base du malaise spécifique dont souffre le patient et/ou de la réponse du test in vitro de l'aptitude des molécules GAG spécifiques définies pour traiter, inhiber et/ou prévenir le malaise dans le prélèvement du patient.

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