Methods of sensitizing cancer to therapy-induced cytotoxicity

Details Methods of sensitizing cancer to therapy-induced cytotoxicity Methods of sensitizing cancer to therapy-induced cytotoxicity

A - Human Necessities

61

K

A61K 31/409 (2006.01)

Patent

CA 2628110

The present application demonstrates that Salinosporamide A can be used to sensitize cancer cells to cancer therapy. Furthermore, the present application demonstrates that Salinosporamide A acts as a therapeutic agent to kill or inhibit cancer cells after sensitization of the cells by an antibody or other chemosensitizing reagents. The cancer cells can be either therapy-sensitive or therapy resistant. The present application further demonstrates that Salinosporamide A induces the expression of Raf kinase inihibitor protein (RKIP) and PTEN, tumor suppressor proteins, and inhibits the expression of YYl, a transcriptional regulator protein overexpressed in cancer cells and also inhibits the growth factor pleiotrophin (PTN).

L'invention démontre qu'il est possible d'utiliser le salinosporamide A pour sensibiliser des cellules cancéreuses à des thérapies anticancéreuses. Le procédé selon l'invention démontre également que le salinosporamide A agit comme agent thérapeutique pour détruire ou inhiber les cellules cancéreuses après sensibilisation des cellules par un anticorps ou par d'autres réactifs de chimiosensibilisation. Les cellules cancéreuses peuvent être sensibles à la thérapie ou résistantes à la thérapie. L'invention démontre également que le salinosporamide A induit l'expression d'une protéine inhibitrice de l'activité kinase de Raf, RKIP et PTEN, des protéines suppressives de tumeurs, et inhibe l'expression de YY1, une protéine de régulation transcriptionnelle surexprimée dans les cellules cancéreuses et inhibe également le facteur de croissance pleiotrophine (PTN). .

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