Methods of separating ftc isomers and derivatives thereof

Details Methods of separating ftc isomers and derivatives thereof Methods of separating ftc isomers and derivatives thereof

C - Chemistry, Metallurgy

07

D

C07D 411/04 (2006.01)

Patent

CA 2375075

The present invention relates to a method of preparing enantiomers and diastereomers of a 2', 3'-dideoxy-5-fluoro-3' thiocytadine (FTC) or a derivative thereof as represented by the structural formula (I), wherein R is H, a substituted or unsubstituted organic acid radical, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heteroarakyl group, a substitute or unsubstituted cycloalkyl group, a substituted or unsubstituted heterocycloalkyl group, a substituted or unsubstituted cycloalkylalkyl, a substituted or unsubstituted heterocycloalkylalkyl, a sugar or a protecting group.

La présente invention concerne un procédé de préparation d'énantiomères et de diastéréomères d'un 2', 3'-dideoxy-5-fluoro-3' thiocytadine (FTC) ou d'un de ses dérivés correspondant à la formule structurelle suivante: Dans cette formule structurelle I, R est H, un radical acide organique substitué ou non, un groupe alkyle substitué ou non, un groupe aryle substitué ou non, un groupe hétéroaryle substitué ou non, un groupe aralkyle substitué ou non, un groupe hétéroaralkyle substitué ou non, un groupe cycloalkyle substitué ou non, un groupe hétérocycloalkyle substitué ou non, un cycloalkylalkyle substitué ou non, un hétérocycloalkylalkyle substitué ou non, un sucre ou un groupe protecteur.

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