Methods of stratifying adolescent idiopathic scoliosis,...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/12 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2682112

A method of stratifying a subject having adolescent idiopathic scoliosis (AIS) comprising: providing a cell sample isolated from the subject; detecting Paired-like homeodomain transcription factor 1 (Pitxi ) expression in the cell sample; whereby the results of the detecting step enables the stratification of the subject having AIS as belonging to an AIS subclass.

L'invention porte sur un procédé de stratification d'un sujet présentant une scoliose idiopathique de l'adolescence (AIS). Ce procédé comprend les opérations consistant : à prélever un échantillon de cellules isolé à partir du sujet; détecter l'expression dans l'échantillon de cellules du facteur de transcription 1 à homéodomaines de type appariés (Pitxi), ce par quoi les résultats de l'étape de détection permettent la stratification du sujet présentant une AIS comme appartenant à une sous-classe d'AIS.

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