Methods of suppressing autoimmune response

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/10 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C07K 14/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2158932

Tissue cells of an animal transformed with a recombinant vector construct that (a) expresses a protein or active portion thereof; (b) transcribes an antisense message; or (c) transcribes a ribozyme capable of inhibiting MHC antigen presentation for use in suppressing an autoimmune response are provided. In a related aspect, the cells are transformed with two or more proteins, antisense or ribozymes, or combinations thereof.

Cellules tissulaires d'un animal transformées à l'aide d'un vecteur de recombinaison qui (a) exprime une protéine ou une partie active de ladite protéine, (b) transcrit un message non codant ou (c) transcrit un ribozyme capable d'inhiber la présentation d'antigènes du complexe majeur d'histocompatiblité (MHC), destinées à être utilisées pour supprimer une réponse auto-immune. Dans un aspect associé, lesdites cellules sont transformées avec au moins deux protéines, deux messages non codants ou deux ribozymes ou des combinaisons de ceux-ci.

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