Methods of suppressing graft rejection

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/86 (2006.01) A61K 35/12 (2006.01) A61K 35/28 (2006.01) A61K 35/39 (2006.01) A61K 48/00 (2006.01) C07K 14/045 (2006.01) C07K 14/075 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2158933

Tissue cells of an animal transformed with a recombinant vector construct which (a) directs the expression of a protein or active portion thereof; (b) transcribes an antisense message; or (c) transcribes a ribozyme capable of inhibiting MHC antigen presentation are provided. In a related aspect, the cells are transformed with two or more of such proteins, antisense or ribozymes, or combinations thereof. The tissue cells are particularly useful within methods for suppressing graft rejection. Pharmaceutical compositions comprising such transformed tissue cells are also provided.

Cette invention concerne des cellules tissulaires d'un animal qu'on a transformées avec une structure de vecteur de recombinaison qui (a) dirige l'expression d'une protéine ou d'une partie active de cette dernière; (b) transcrit un message non codant; ou (c) transcrit un ribozyme capable d'inhiber la présentation de l'antigène du complexe majeur d'histocompatibilité. Selon un autre aspect, les cellules sont transformées à l'aide de deux ou plusieurs de ces protéines, message non codant ou ribozymes, ou avec des combinaisons de ces derniers. Ces cellules tissulaires sont tout particulièrement utiles dans des procédés de suppression des rejets de greffes. Cette invention concerne également des compositions pharmaceutiques comprenant lesdites cellules tissulaires transformées.

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