Methods of suppressing immune response by gene therapy

Details Methods of suppressing immune response by gene therapy Methods of suppressing immune response by gene therapy

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C12N 5/10 (2006.01) C12N 9/24 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2158934

Tissue cells of an animal transformed with a multivalent recombinant vector construct are provided. The vector construct expresses a therapeutic protein and either (a) a second protein or active portion thereof capable of inhibiting MHC antigen presentation; (b) an antisense message capable of inhibiting MHC antigen presentation; or (c) a ribozyme capable of inhibiting MHC antigen presentation. Pharmaceutical compositions comprising such multivalent constructs are also provided. The transformed tissue cells are particularly useful within methods for suppressing an immune response.

Cette invention concerne des cellules tissulaires d'origine animale qu'on a transformées avec une structure multivalente de vecteur de recombinaison. La structure de vecteur exprime une protéine thérapeutique et soit (a) une deuxième protéine ou une partie active de cette dernière qui est capable d'inhiber l'apparition de l'antigène du complexe majeur d'histocompatibilité (CMH); (b) un message anti-sens qui est capable d'inhiber l'apparition de l'antigène CMH; soit (c) un ribozyme qui est capable d'inhiber l'apparition de l'antigène CMH. Cette invention concerne également des compositions pharmaceutiques comprenant ces structures multivalentes. Les cellules tissulaires transformées sont tout particulièrement utiles dans des procédés de suppression de la réponse immunitaire.

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