Methods of surface modification of a flexible substrate to...

Details Methods of surface modification of a flexible substrate to... Methods of surface modification of a flexible substrate to...

C - Chemistry, Metallurgy

12

M

C12M 3/00 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2537994

The present invention provides methods of producing a surface with enhanced cell~adhesive properties comprising applying a stress to a polymeric matrix. The strained matrix is then modified by grafting a self-assembled monolayer onto the strained matrix, with the self~-assembled monolayer comprising at least one exposed functional group. At least one cell~adhesive molecule can then be coupled to the at least one exposed functional group on the self- ~assembled monolayer to produce a surface with enhanced cell-adhesive properties.

La présente invention concerne des procédés de production d'une surface présentant des propriétés d'adhésion cellulaire améliorées, consistant à appliquer une contrainte sur une matrice polymère. La matrice contrainte est ensuite modifiée par greffage d'une monocouche auto-assemblée sur la matrice contrainte, la monocouche auto-assemblée comprenant au moins un groupe fonctionnel exposé. Au moins une molécule d'adhésion cellulaire peut être couplée avec le ou les groupes fonctionnels exposés sur la monocouche auto-assemblée afin de produire une surface présentant des propriétés d'adhésion cellulaire améliorées.

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