C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/44 (2006.01) C07C 271/22 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2608589
The present invention is directed to a method of synthizing compounds of formula (I), wherein X, Z, V, R1, R3, R4, G2, n, x, y, and z are defined herein. This invention also includes a method of preparing acid compounds of formula (VII), wherein R is H, and R4, x, y, and z are as defined herein and PG is a protecting group. This invention is also directed to (E) N-{4-[3- chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4- (methylamino)-2-butenamide, compositions containing it and methods of using the to treat cancer.
L'invention se rapporte à un procédé de synthèse de composés de formule (I) dans laquelle X, Z, V, R1, R3, R4, G2, n, x, y, et z sont tels que définis dans la description. L'invention concerne également un procédé de préparation de composés acides de formule (VII) dans laquelle R désigne H, et dans laquelle R4, x, y, et z sont tels que définis dans la description et PG est un groupe protecteur. Cette invention concerne également (E) N-{4-[3-chloro-4-(2-pyridinylméthoxy)anilino]-3-cyano-7-éthoxy-6-quinolinyl}-4-(méthylamino)-2-buténamide, des compositions renfermant ledit composé et des procédés d'utilisation desdits composés dans le traitement du cancer.
Chew Warren
Discafani-Marro Caroyln
Mcginnis John Patrick II
Rabindran Sridhar Krishna
Wang Youchu
Torys Llp
Wyeth
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