Methods of synthesizing substituted 3-cyanoquinolines and...

Details Methods of synthesizing substituted 3-cyanoquinolines and... Methods of synthesizing substituted 3-cyanoquinolines and...

C - Chemistry, Metallurgy

07

D

C07D 215/56 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2609186

The invention is directed to methods of making substituted 3- cyanoquinolines, including compounds according to the following formula: (IV) The methods are amenable to large scale manufacture, avoid the use of chromatographic separations, and provide stable, high purity product more efficiently than in the prior art.

L'invention concerne des procédés pour réaliser des 3-cyanoquinoléines substituées, y compris des composés de formule: (IV). Ces procédés sont adaptés à la production à grande échelle, ils évitent l'application de séparations chromatographiques et fournissent un produit stable et de grande pureté de manière plus rentable que la technique actuelle.

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