Methods of therapy for b cell-related cancers

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) A61K 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2544368

Methods of treating a human subject for a cancer characterized by neoplastic B cell growth are provided. The methods comprise administering combination antibody therapy to the subject, where an effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof in combination with an anti-CD20 antibody or antigen~binding fragment thereof is administered to the subject. The invention further comprises pharmaceutical compositions with combinations of these antibodies in a pharmaceutically acceptable carrier.

La présente invention a trait à des procédés de traitement d'un sujet humain pour un cancer caractérisé par la croissance de la cellule B néoplasique. Les procédés comprennent l'administration d'une thérapie de combinaison d'anticorps au sujet, où une quantité efficace d'un anticorps antagoniste anti-CD40 ou un fragment de liaison à l'antigène de celui-ci en combinaison avec un anticorps anti-CD40 ou un fragment de liaison à l'antigène de celui-ci est administré au sujet. L'invention a également trait à des compositions pharmaceutiques avec des combinaisons de ces anticorps dans un support pharmaceutiquement acceptable.

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