A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/20 (2006.01) A61P 35/02 (2006.01)
Patent
CA 2534215
Methods for treating a human with chronic lymphocytic leukemia using a combination of an interleukin-2 and an anti-CD52 antibody are provided. These therapeutic agents are administered as two separate pharmaceutical compositions, one containing an IL-2, the other containing an anti-CD2 antibody, according to a dosing regiment. Administering of these two therapeutic agents together results in a positive therapeutic response that is improved with respect to that observed with anti-CD52 antibody alone.
L'invention concerne des méthodes destinées au traitement d'un humain atteint de la leucémie lymphocytaire chronique, consistant à combiner une interleukine-2 avec un anticorps anti-CD52. Ces agents thérapeutiques sont administrés sous forme de deux compositions pharmaceutiques différentes, l'une contenant une IL-2, l'autre un anticorps anti-CD2, selon un schéma posologique précis. L'administration de ces deux agent thérapeutiques ensemble permet d'obtenir une réponse thérapeutique positive qui est meilleure par rapport à celle observée lors de l'utilisation d'un anticorps anti-CD52 seul.
Hurst Deborah
Milan Sandra
Osterborg Anders
Quadt Cornelia
Wolin Maurice J.
Borden Ladner Gervais Llp
Chiron Corporation
Karolinska University Hospital
Novartis Vaccines And Diagnostics Inc.
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