Methods of therapy for non-hodgkin's lymphoma

Details Methods of therapy for non-hodgkin's lymphoma Methods of therapy for non-hodgkin's lymphoma

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/20 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2469045

Methods for treating a human with lymphoma using a combination of interleukin- 2 and at least one anti-CD20 antibody are provided. These therapeutic agents are administered as two separate pharmaceutical compositions, one containing IL-2, the other containing at least one anti-CD20 antibody, according to a dosing regimen. Administering of these two therapeutic agents together potentiates the effectiveness of either agent alone, resulting in a positive therapeutic response that is improved with respect to that observed with either agent alone. The therapeutic effects of these agents can be achieved using lower dosages of IL-2, thereby lessening the toxicity of prolonged IL-2 administration and the potential for tumor escape.

L'invention concerne des méthodes de traitement d'un être humain atteint d'un lymphome à l'aide d'une combinaison d'interleukine-2 et d'au moins un anticorps anti-CD20. Ces agents thérapeutiques sont administrés dans deux compositions pharmaceutiques séparées, une contenant l'IL-2, l'autre contenant au moins un anticorps anti-CD20, selon un régime de dosage. L'administration conjointe de ces deux agents thérapeutiques augmente l'efficacité d'un quelconque des deux agents utilisé individuellement, permettant d'obtenir une réponse thérapeutique positive améliorée par rapport à celle observée avec un quelconque des deux agents utilisé individuellement. Les effets thérapeutiques de ces agents peuvent être obtenus par utilisation de dosages inférieurs d'IL-2, réduisant ainsi la toxicité d'une administration d'IL-2 prolongée et le potentiel d'échappement tumoral.

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