A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/29 (2006.01) A61K 38/18 (2006.01)
Patent
CA 2249212
Compositions of proteins with chondrocyte and cartilaginous tissue inducing activity, as well as method of using those compositions, are disclosed. The compositions comprise one or more proteins of the transforming growth factor- .beta. (TGF-.beta.) superfamily of proteins, particularly bone morphogenetic proteins (BMPs), in combination with parathyroid hormone-related polypeptide (PTHrP) or an equivalent PTH-like polypeptide. The compositions and methods are useful in the treatment of osteoarthritis, cartilage defects and in related tissue repair.
L'invention concerne des compositions de protéines présentant une activité induisant les chondrocytes et le tissu cartilagineux, ainsi qu'un procédé d'utilisation de ces compositions. Les compositions comprennent une ou plusieurs protéines de la superfamille de protéines du facteur transformant de croissance-.beta. (TGF-.beta.), notamment des protéines morphogénétiques osseuses BMP, en combinaison avec un polypeptide apparenté à l'hormone parathyroïdienne (PTHrP) ou un polypeptide de type PTH équivalent. Les compositions et les procédés sont utiles dans le traitement de l'arthrose, de défauts du cartilage et dans la réparation des tissus associés.
Hattersley Gary
Rosen Vicki A.
Genetics Institute Inc.
Genetics Institute Llc
Gowling Lafleur Henderson Llp
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