Methods of treating age associated memory impairment (aami),...

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A61K 31/65 (2006.01) A61K 31/19 (2006.01) A61K 31/404 (2006.01) A61K 31/436 (2006.01) A61K 31/4418 (2006.01) A61K 31/453 (2006.01) A61K 31/4545 (2006.01) A61K 31/52 (2006.01) A61K 31/5513 (2006.01) A61K 31/60 (2006.01) A61K 31/616 (2006.01) A61K 31/635 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2499599

Therapeutic methods for treatment of age associated memory impairment (AAMI), mild cognitive impairment (MCI), Alzheimer's disease (AD), cerebrovascular dementia (CVD), and related neurodegenerative conditions by administering an agent capable of inhibiting cell cycle progression, comprising administering one or more agents that are capable of inhibiting neuronal cell cycle progression at either an early cell cycle phase or generally, either alone or in combination with one or more agents capable of reducing mitogenic stimulation.

Cette invention se rapporte à des procédés thérapeutiques servant à traiter les altérations de la mémoire liées à l'âge (AAMI), les déficits cognitifs légers (MCI), la maladie d'Alzheimer, la démence cérébro-vasculaire (CVD) et les états neurodégénératifs apparentés, en administrant un agent capable d'inhiber la progression du cycle cellulaire, ce procédé consistant à administrer un ou plusieurs agents capables d'inhiber la progression du cycle cellulaire neuronal soit dans une phase précoce du cycle cellulaire soit, de façon générale, seul ou associé à un ou plusieurs agents capables de réduire la stimulation mitogène.

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