Methods of treating asthma

Details Methods of treating asthma Methods of treating asthma

G - Physics

01

N

G01N 33/53 (2006.01)

Patent

CA 2545722

Methods for agents useful for treating asthma are disclosed. The methods include screening for agents that inhibit the production of a PKC-.theta. protein, as well as for agents that inhibit the kinase activity of a PKC- .theta. protein, or a functional fragment thereof, wherein such agents are useful for treating asthma. The methods also include screening for agents that inhibit the production of a reporter gene product encoded by a nucleic acid sequence operably linked to a PKC-.theta. promoter. Also disclosed are methods of treating asthma that include administering an agent that inhibits the production of a functional PKC-.theta. protein or the kinase activity of a PKC- .theta. protein or a functional fragment thereof. An isolated mast cell lacking expression of endogenous PKC-.theta. is also disclosed.

Cette invention concerne des méthodes pour des agents permettant de traiter l'asthme. Ces méthodes consistent à cribler des agents qui inhibent la production d'une protéine PKC-?, ainsi que des agents qui inhibent l'activité kinase d'une protéine PKC-?, ou un fragment fonctionnel de celle-ci, ces agents étant utiles pour traiter l'asthme. Les méthodes décrites dans cette invention consistent également à cribler des agents qui inhibent la production d'un produit de gène rapporteur codé par une séquence d'acides nucléiques opérationnellement liée à un promoteur PKC-?. L'invention concerne également des méthodes permettant de traiter l'asthme, lesquelles méthodes consistent à administrer un agent qui inhibe la production d'une protéine PKC-? fonctionnelle ou l'activité kinase d'une protéine PKC-? ou un fragment fonctionnel de celle-ci. En outre, on décrit un mastocyte isolé ne présentant aucune expression de la PKC-? endogène.

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