Methods of treating asthma with o-desulfated heparin

Details Methods of treating asthma with o-desulfated heparin Methods of treating asthma with o-desulfated heparin

A - Human Necessities

61

K

A61K 31/727 (2006.01)

Patent

CA 2261872

A method for reducing asthmatic response in a mammal comprising administering a response-reducing amount of O-desulfated heparin to the mammal, thereby reducing the asthmatic response. The amount can be administered by aerosolization. The O-desulfated heparin has O-desulfation at least at the 2-O and 3-O positions. The cholinergic neural pathways and muscarinic receptor subtypes of the afferent sensory and efferent motor limbs of the vagus nerve innervation of the lung airway is depicted in the Figure.

Procédé permettant de réduire la réaction asthmatique chez un mammifère et comportant l'administration audit mammifère d'une certaine dose d'héparine o-désulfatée réductrice de réaction, réduisant ainsi sa réaction asthmatique. La dose mentionnée peut être administrée sous forme d'aérosols. Ladite héparine o-désulfatée possède une o-désulfatation au moins dans les positions 2-O et 3-O. La figure décrit les voies neuronales parasympathomimétiques et les sous-types de récepteurs muscariniques de l'innervation du nerf pneumogastrique du conduit aérien pulmonaire.

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