A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2649440
Methods for treating patients with autoimmune diseases are disclosed. The methods of the application include first depleting circulating lymphocytes in the mammal, e.g., by administering anti-thymocyte antibody, and then, during the course of repopulation, administering to the mammal a therapeutically effective amount of latent TGF-.beta. and/or another agent that promotes expansion of regulatory T cells. In certain aspects, the disclosed process results in improved kidney function and survival rates.
La présente invention concerne des procédés de traitement de patients qui ont une maladie auto-immune. Lesdits procédés comprennent une première étape d'appauvrissement des lymphocytes circulants chez le mammifère, par exemple par l'administration d'un anticorps anti-thymocyte, puis, au cours de la repopulation, l'administration au mammifère d'une quantité thérapeutiquement efficace de TGF-.beta. latent et/ou d'un autre agent qui favorise le développement des lymphocytes T régulateurs. Dans certains aspects, le procédé selon l'invention se traduit par l'amélioration de la fonction rénale et des taux de survie.
Kaplan Johanne
Mcpherson John M.
Genzyme Corporation
Mbm Intellectual Property Law Llp
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