A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/425 (2006.01) A61K 31/415 (2006.01) A61K 31/427 (2006.01) C07D 333/38 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2360233
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, like inflammation, sepsis, tissue damage, autoimmune disorders, adult respiratory distress syndrome, hemolytic anemia, myasthenia gravis, immune complex induced vasculitis, glomerulonephritis, arthritis, allergic neuritis, graves disease, insulin resistance, systemic lupus erythematosus, graft rejection, neurodegenerative diseases including Alzheimer's disease, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4, X, Y and Z are defined in the specification.
L'invention concerne une méthode de traitement des symptômes d'une pathologie aiguë ou chronique, induite par le mécanisme d'action classique de la cascade du complément, consistant à administrer à un mammifère nécessitant un tel traitement, une dose efficace sur le plan thérapeutique d'un composé correspondant à la formule (I), ou d'un solvate, hydrate ou sel de celui-ci, acceptable sur le plan pharmacologique. Dans cette formule, R?1¿, R?2¿, R?3¿, R?4¿, X, Y et Z possèdent les notations données dans la description.
Bone Roger F.
Hoffman James B.
Illig Carl R.
Klein Scott L.
Randle Troy L.
3-Dimensional Pharmaceuticals Inc.
Mbm & Co.
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