A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/20 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2566745
Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.
Cette invention concerne des procédés servant à traiter le cancer par administration conjointe d'un anticorps monoclonal thérapeutique et d'interleukine IL-21. A titre d'exemple, des anticorps monoclonaux pouvant être utilisés sont le rituximab, le trastuzumab et des anticorps anti-CTLA-4. L'effet antitumoral amélioré de cette polythérapie est particulièrement utile chez des populations de patients qui sont récalcitrantes à une thérapie monoclonale, qui récidivent après traitement avec des anticorps monoclonaux ou dans lesquelles l'effet antitumoral amélioré de l'IL-21 réduit les toxicités associées à un traitement utilisant ces anticorps monoclonaux.
Clegg Christopher H.
Foster Donald C.
Heipel Mark D.
Holly Richard D.
Hughes Steven D.
Smart & Biggar
Zymogenetics Inc.
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