Methods of treating cancer using modified c-reactive protein

Details Methods of treating cancer using modified c-reactive protein Methods of treating cancer using modified c-reactive protein

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 9/127 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01)

Patent

CA 2132001

The invention provides a method of treating cancer in a mammal comprising administering to the mammal an effective amount of modified C-reactive protein ("mCRP"). The invention also provides a method of treating cancer in a mammal comprising administering to the mammal mCRP in combination with another agent such as a chemotherapeutic compound, immunoadjuvant, or cytokine. The mCRP may be administered to the mammal in a pharmaceutically-acceptable carrier or in liposomes. The invention further provides a method of identifying cancer cells in a mammal using mCRP as an imaging agent.

L'invention se rapporte à un procédé de traitement du cancer chez un mammifère comprenant l'administration à ce dernier d'une quantité efficace de la protéine C-réactive modifiée (''mCRP''). L'invention se rapporte également à un procédé de traitement du cancer chez un mammifère comprenant l'administration à ce dernier de la protéine mCRP combinée à un autre agent, tel qu'un composé chimiothérapique, un immunoadjuvant ou une cytokine. On peut administer la protéine mCRP au mammifère dans un agent porteur pharmaceutiquement acceptable ou dans des liposomes. L'invention décrit, de plus, un procédé d'identification de cellules cancéreuses chez un mammifère utilisant la protéine mCRP en tant qu'agent d'imagerie.

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