Methods of treating cancer using notch pathway inhibitors

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C07K 14/435 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2701686

The present invention is based on the discovery that the Notch signaling pathway is associated with cancer. Accord-ingly, the invention provides methods and compositions for treating cancer. Also provided are methods of modulating the expression and/or activity of proteins in the Notch signaling pathway for use in diagnoses and treatment of cancer in a subject.

La présente invention concerne la découverte selon laquelle la voie de signalisation de Notch est associée au cancer. En conséquence, l'invention concerne des procédés et des compositions destinés au traitement du cancer. L'invention concerne également des procédés de modulation de l'expression et/ou de l'activité de protéines dans la voie de signalisation de Notch en vue d'une utilisation pour des diagnostics et le traitement du cancer chez un sujet.

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