A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/712 (2006.01) C12N 15/113 (2010.01) A61P 35/00 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2758005
One aspect of the invention provides methods for treating cancers which are resistant to treatment with a protein tyrosine kinase inhibitor by co-treatment with the protein tyrosine kinase inhibitor and one or more antisense oligomers that reduce the expression of HER3 and/or HER2 and/or EGFR. Another aspect of the invention provides methods for treating cancers by co-treatment with an inhibitor of HER2 and one or more antisense oligomers that reduce the expression of HER3.
Selon un aspect, l'invention porte sur des procédés de traitement de cancers qui sont résistants à un traitement par un inhibiteur de protéine tyrosine kinase, par un co-traitement avec l'inhibiteur de protéine tyrosine kinase et un ou plusieurs oligomères anti-sens qui réduisent l'expression de HER3 et/ou HER2 et/ou EGFR. Un autre aspect de l'invention porte sur des procédés pour traiter des cancers par un co-traitement avec un inhibiteur de HER2 et un ou plusieurs oligomères anti-sens qui réduisent l'expression de HER3.
Greenberger Lee Martin
Qu Zhengxing
Zhang Yixian
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Enzon Pharmaceuticals Inc.
Santaris Pharma A/s
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