A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/282 (2006.01) A61K 31/16 (2006.01)
Patent
CA 2626679
The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof an amount of a histone deacetylase (HDAC) inhibitor, e.g., suberoylanilide hydroxamic acid (SAHA), or a pharmaceutically acceptable salt or hydrate thereof, and an amount of one or more anticancer agents such as Carboplatin or Paclitaxel. The HDAC inhibitor and the anticancer agents may be administered to comprise therapeutically effective amounts.
La présente invention concerne une méthode destinée à traiter un cancer chez un sujet le nécessitant et consistant à administrer à ce sujet une dose d'un inhibiteur d'histone désacétylase (HDAC) tel que l'acide hydroxamique suberoylanilide (SAHA), ou un sel ou un hydrate pharmaceutiquement acceptable de ce composé, ainsi qu'une dose d'un ou plusieurs agents anticancéreux tels que le carboplatine ou le paclitaxel. Cet inhibiteur de HDAC et ces agents anticancéreux peuvent être administrés en doses thérapeutiquement efficaces.
Belani Chandra
Chiao Judy
Frankel Stanley
Paradise Carolyn
Ramalingam Suresh Sakkarai
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
University Of Pittsburgh-Of The Commonwealth System Of Higher Ed
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