Methods of treating ccr2 mediated diseases or disorders

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/22 (2006.01) A61K 31/137 (2006.01) A61K 31/365 (2006.01) A61K 31/454 (2006.01) A61K 31/4985 (2006.01) A61K 31/499 (2006.01) A61K 38/17 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2575612

The present invention provides methods to decrease or maintain body weight and/or body fat in patients, e.g. humans and animals, for example in the treatment of overweight or obese patients, or as a means to produce leaner meat in food stock animals, e.g., cattle, chickens, pigs, alone or in combination with second therapeutic agent; methods to treat diabetes and/or glucose intolerance; and methods to treat metabolic syndrome disorders in patients in need thereof, by administering a CCR2 therapeutic agent, kits for the above-identified therapeutic uses, and methods of identifying CCR2 therapeutic agents for treating the above-described therapeutic uses.

La présente invention concerne des méthodes qui permettent de diminuer ou de stabiliser le poids corporel et/ou la masse adipeuse dans le corps de patients, humains ou animaux, notamment pour le traitement de patients de poids excédentaire ou obèses, ou en tant que moyen de production de viande plus maigre chez des animaux de boucherie, tels que le bétail, la volaille, les cochons, seul ou en combinaison avec un second agent thérapeutique. L'invention concerne également des méthodes de traitement du diabète et/ou de l'intolérance au glucose; et des méthodes de traitement de troubles du syndrome métabolique chez des patients nécessitant un tel traitement, par administration d'un agent thérapeutique CCR2. L'invention concerne en outre des méthodes d'identification d'agents thérapeutiques CCR2 destinés au traitement des états ci-décrits.

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