Methods of treating cellular proliferative disease using...

Details Methods of treating cellular proliferative disease using... Methods of treating cellular proliferative disease using...

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 31/52 (2006.01)

Patent

CA 2569279

A method of treating a cellular proliferative disorder in a patient through the use of a naphthalimide and a PARP-1 inhibitor is disclosed. In one embodiment the naphthalimide is amonafide or an analog thereof. Fig. 9 depicts an increase in inhibition of cellular growth observed after treatment with amonafide in combination or sequentially with nicotinamide or caffeine in an in vitro cell viability assay.

L'invention concerne un procédé destiné à traiter une maladie proliférative cellulaire chez un patient au moyen d'un naphtalimide et d'un inhibiteur de PARP-1. Dans l'un des modes de réalisation, le naphtalimide consiste en de l'amonafide ou un analogue de celui-ci.

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