Methods of treating conditions associated with an edg-1...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/00 (2006.01) A61K 31/415 (2006.01) A61K 31/4439 (2006.01) A61K 31/685 (2006.01) A61K 38/19 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2466288

In one aspect, the present invention provides a method of modulating an Edg-1 receptor mediated biological activity in a cell. A cell expressing the Edg-1 receptor is contacted with a modulator of the Edg-1 receptor sufficient to modulate the Edg-1 receptor mediated biological activity. In another aspect, the present invention provides a method for modulating an Edg-1 receptor mediated biological activity in a subject. A therapeutically effective amount of a modulator of the Edg-1 receptor is administered to the subject.

Dans un aspect, la présente invention concerne un procédé pour moduler une activité biologique dans une cellule à médiation par un récepteur Edg-1. Une cellule exprimant le récepteur Edg-1 est mise en contact avec un modulateur du récepteur Edg-1, suffisant pour moduler l'activité biologique à médiation par Edg-1. Dans un autre mode de réalisation, l'invention concerne un procédé pour moduler une activité biologique à médiation par Edg-1 chez un sujet. On administre au sujet une quantité thérapeutiquement efficace d'un modulateur du récepteur Edg-1.

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