Methods of treating degenerative disorders with rac 1b...

A - Human Necessities – 61 – K

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A61K 31/7088 (2006.01) A61K 38/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2638887

The invention relates to compositions and methods for treating degenerative disorders. More particularly, the invention relates to methods of treating amyloïd beta peptide-related disorders, particularly Alzheimer's disease, using Rac1b inhibitors. The invention may be used in mammalian subjects, particularly human subjects, at various stages of the disease, including disease onset. The invention also provides methods of producing, identifying, selecting or optimising compounds for use in the treatment of amyloïd beta peptide-related disorders, based on a determination of the ability of a test compound to inhibit Rac1b.

L'invention concerne des compositions et des méthodes pour traiter des troubles dégénératifs. Plus particulièrement, l'invention concerne des méthodes pour traiter des troubles liés au peptide bêta-amyloïde, en particulier la maladie d'Alzheimer, au moyen d'inhibiteurs de Rac1b. L'invention peut être utilisée chez des sujets mammifères, en particulier des sujets humains, à différents stades de la maladie, y compris en début de maladie. L'invention concerne aussi des méthodes pour produire, identifier, sélectionner ou optimiser des composés à utiliser dans le traitement de troubles liés au peptide bêta-amyloïde, en fonction d'une détermination de la capacité d'un composé de test d'inhiber le Rac1b.

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