A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01)
Patent
CA 2666613
The invention relates, in general, to markers of obesity and lipodystrophy. In particular, the expression level of the SLUG gene or its expression products can be used as such a marker. Furthermore, the invention additionally relates to the use of SLUG as a therapeutic and diagnostic target for these pathologies. The invention further relates to a method of treating a disorder associated with increased or decreased fat storage in a mammal comprising modulating the activity or level of the SLUG protein or the SLUG gene in the mammal.
La présente invention concerne d'une manière générale des marqueurs d'obésité et de lipodystrophie. En particulier, le niveau d'expression du gène SLUG ou de ses produits d'expression peut être utilisé en tant que marqueur. L'invention concerne en outre l'utilisation du gène SLUG en tant que cible thérapeutique et diagnostique pour ces pathologies. L'invention concerne également un procédé permettant de traiter un trouble associé à un stockage accru ou réduit de graisse chez un mammifère, le procédé consistant à moduler l'activité ou le niveau de la protéine SLUG ou du gène SLUG chez un mammifère.
Perez-Mancera Pedro A.
Sanchez-Garcia Isidro
Consejo Superior de Investigaciones Cientificas
Gowling Lafleur Henderson Llp
Universidad de Salamanca
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