Methods of treating disorders of non-visual sensory epithelia

Details Methods of treating disorders of non-visual sensory epithelia Methods of treating disorders of non-visual sensory epithelia

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2237400

In general, the present invention provides methods for promoting the function of inner ear cells using neuregulins. A novel aspect of the invention involves the use of neuregulins as growth factors to promote function of non-visual sensory epithelial cells. Trteating of the non-visual sensory epithelial cells to provide these effects may be achieved by contacting non-visual sensory epithelial cells with a polypeptide described herein. The treatments may be provided to slow or halt net cell loss or to increase the amount or quality of non-visual sensory epithelial tissue present in the vertebrate.

D'une manière générale, la présente invention concerne des procédés permettant de promouvoir la fonction de cellules de l'oreille interne en utilisant des neurégulines. Un aspect nouveau de l'invention concerne l'emploi de neurégulines comme facteurs de croissance, pour promouvoir la fonction de cellules épithéliales sensorielles non visuelles. Le traitement de ces cellules pour obtenir ces effets peut être effectué en mettant lesdites cellules en contact avec un polypeptide qui figure dans la description. Les traitements peuvent être appliqués pour ralentir ou arrêter la perte nette de cellules ou pour accroître la quantité ou la qualité du tissu épithélial sensoriel non visuel qui existe chez le vertébré considéré.

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