A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/12 (2006.01) A61K 38/39 (2006.01)
Patent
CA 2627974
The present invention has demonstrated for the first time that orally administered type I collagen (CI) induced tolerance to CI in patients suffering from systemic sclerosis (SSc) and ameliorated clinical manifestations of the disease. Accordingly, the present invention provides methods of treating a fibrosing disease by oral administration of a tissue protein, for example, collagen, derived from the tissue undergoing fibrosis.
La présente invention a démontré pour la première fois que du collagène (CI) de type I administré oralement induit une tolérance au CI chez des patients qui souffrent de sclérose systémique (SSc) et améliore les manifestations cliniques de la maladie. En conséquence, la présente invention concerne des méthodes de traitement d'une maladie fibrosante par administration orale d'une protéine tissulaire, par exemple, du collagène, dérivée du tissu devenant fibreux.
Kang Andrew H.
Postlethwaite Arnold E.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The University Of Tennessee Research Foundation
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