A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/135 (2006.01) A61K 31/277 (2006.01) A61K 31/36 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01)
Patent
CA 2485736
This invention provides a method of treating functional gastrointestinal and genitourinary disorders in a mammal by administering to the mammal an effective amount of hydroxycycloalkane phenethylamine of the following structural formula (I) in which A is a moiety of the formula (II) where the dotted line represents optional unsaturation; R1 is hydrogen or alkyl; R2 is alkyl; R4 is hydrogen, alkyl, formyl, or alkanol; R5 and R6 are, independently, hydrogen, hydroxyl, alkyl, alkoxy, alkanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alkanamido, halo, trifluoromethyl, or taken together, methylene dioxy; R7 is hydrogen or alkyl; and n is 0, 1, 2, 3, or 4, or a pharmaceutically acceptable salt thereof.
La présente invention concerne une méthode de traitement de troubles fonctionnels gastro-intestinaux et génito-urinaires chez un mammifère par administration d'une quantité efficace d'hydroxycycloalcane phénéthylamine de formule structurale suivante (I) dans laquelle A représente une fraction de la formule (II) où la ligne en pointillés représente une insaturation éventuelle; R¿1? représente hydrogène ou alkyle; R¿2? représente alkyle; R¿4? représente hydrogène, alkyle, formyle, ou alcanole; R¿5? et R¿6? représentent, indépendamment, hydrogène, hydroxyle, alkyle, alkoxy, alcanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alcanamido, halo, trifluorométhyle, ou pris ensemble, méthylènedioxy; R¿7? représente hydrogène ou alkyle; et n représente 0, 1, 2, 3, ou 4, ou son sel pharmaceutiquement acceptable.
Burton Michael Scott
Danilewitz Mervyn
Karlstadt Robyn Gail
Lynn Richard Brian
Torys Llp
Wyeth
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