Methods of treating infection by drug resistant bacteria

Details Methods of treating infection by drug resistant bacteria Methods of treating infection by drug resistant bacteria

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/4025 (2006.01) A61K 31/454 (2006.01) A61K 31/4725 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61K 31/55 (2006.01) A61P 31/04 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2458926

Methods are provided for treating an infection by Gram-positive bacteria in a mammal, by administering to the mammal an effective amount of a compound that binds noncovalently in the minor groove of duplex DNA, the compound being identified by a number of DNA binding parameters and, in many instances, being a polyaromatic compound.

L'invention concerne des procédés de traitement d'une infection par des bactéries Gram positif chez un mammifère, par administration au mammifère, d'une quantité efficace d'un composé liant, par liaison non covalente, dans la cannelure mineure de l'ADN double brin, le composé étant identifié par une pluralité de paramètres de liaison à l'ADN, et étant, dans bien des cas, un composé polyaromatique.

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