A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61K 31/64 (2006.01) A61K 38/20 (2006.01) A61P 9/10 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2717365
Disclosed herein, in certain embodiments, is a method for treating an MIF-mediated disorder. In some embodi-ments, the method comprises administering an active agent that in-hibits (i) MIF binding to CXCR2 and CXCR4 and/or (ii) MIF-ac-tivation of CXCR2 and CXCR4; (iii) the ability of MIF to form a homomultimer; or a combination thereof
L'invention concerne, dans certains modes de réalisation, un procédé permettant de traiter un trouble médié par MIF. Dans un certain nombre de modes de réalisation, le procédé consiste à administrer un agent actif qui inhibe la liaison de MIF au CXCR2 et CXCR4 et/ou (ii) l'activation de MIF de CXCR2 et CXCR4; (iii) l'aptitude de MIF à former un homomultimère; ou une combinaison de ceux-ci.
Bernhagen Juergen
Schultz Joshua Robert
Vollrath Benedikt
Weber Christian
Zernecke Alma
Carolus Therapeutics Inc.
Gowling Lafleur Henderson Llp
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