Methods of treating inflammation, particularly diabetes

Details Methods of treating inflammation, particularly diabetes Methods of treating inflammation, particularly diabetes

A - Human Necessities

61

K

A61K 35/12 (2006.01) C12N 5/0783 (2010.01) A61K 39/00 (2006.01)

Patent

CA 2437980

A method of treating inflammation and/or diabetes in a mammal involves administering to the mammal an effective anti-inflammatory amount of allogeneic lymphocytic T cells. Among useful cells are TALL-104 cells, ATCC Accession No. CRL 11386, which cells have been modified by stimulation in vitro by treatment with a cytokine and gamma irradiation at a dose suitable to irreversibly arrest cell proliferation. These modified cells are characterized by irreversibly arrested cell proliferation and non-MHC restricted cytotoxic activity. Among other useful cells are TALL-106 cells.

Cette invention se rapporte à un procédé servant à traiter les inflammations et/ou le diabète chez un mammifère et consistant à cet effet à administrer audit mammifère des cellules halogènes du type lymphocytes T en quantité suffisante pour produire un effet anti-inflammatoire. Ces cellules utiles sont notamment les cellules TALL-104, No. de dépôt ATCC CRL 11386, qui ont été modifiées par stimulation in vitro par traitement avec une cytokine et par exposition à un rayonnement gamma à une dose propre à interrompre de façon irréversible la prolifération cellulaire. Ces cellules modifiées se caractérisent par une prolifération cellulaire interrompue de façon irréversible et par une activité cytotoxique non restreinte par MHC. D'autres cellules utiles sont les cellules TALL-106.

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